منابع مشابه
ReviewTwo Decades of RNA Catalysis
enzymology, the sensitive nature of RNA structure Twenty years have passed since the initial discovery brings new complexities to these experiments. Considof catalytic RNA. Although initial discoveries of riboeration of RNA catalysis in general [7, 8] and more spezymes (RNA enzymes) involved phosphoryl transfer cific discussions of ribozyme structure and function [9, reactions on RNA substrates...
متن کاملRNA Aptamer Evolution: Two Decades of SELEction
Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the re...
متن کاملRNA catalysis.
Our understanding of the relationship between the structure of RNA and its catalytic activity has advanced significantly in the past year. These advances include time-resolved crystallographic studies on the hammerhead ribozyme, as well as new structures of a group I intron, a lead(II)-cleavage ribozyme, a hepatitis delta virus ribozyme, and components of the spliceosome machinery and the pepti...
متن کاملMechanisms of RNA catalysis.
Ribozymes are RNA molecules that act as chemical catalysts. In contemporary cells, most known ribozymes carry out phosphoryl transfer reactions. The nucleolytic ribozymes comprise a class of five structurally-distinct species that bring about site-specific cleavage by nucleophilic attack of the 2'-O on the adjacent 3'-P to form a cyclic 2',3'-phosphate. In general, they will also catalyse the r...
متن کاملIsfahan University of Medical Sciences: Two Decades of Scientific Achievements
Introduction: Several studies indicate a significant growth in research activities and scientific achievements in Iran during recent years. Isfahan University of Medical Sciences as a main university has had a special situation in this regard. The aim of this study was to determine science productions of Isfahan University of Medical Sciences since its establishment, during1985 till 2007. Meth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2002
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(02)00217-x